'''Spafford''' may refer to::
* Belle S. Spafford
(1895–1982), former president of the Relief Society
* Gene Spafford
(born 1956), professor of computer science at Purdue University
* Horatio Spafford
(1828-1888), author of the hymn "It Is Well With My Soul"
* Suzy Spafford
(born 1945), cartoonist, creator of "Suzy's Zoo"